Hoehe M, 1988. Influence on the menstrual cycle on neuroendocrine and behavioral responses to an opiate agonist in humans: preliminary results. Psychoneuroendocrinology
Keep an eye on Intently (2)primidone will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers could lead to a reduce in fentanyl plasma concentrations, deficiency of efficacy or, probably, growth of a withdrawal syndrome within a affected individual who may have created physical dependence to fentanyl.
berotralstat will enhance the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Keep track of or titrate substrate dose when berotralstat is coadministered with slender therapeutic index drugs that are CYP3A substrates.
Cases of serotonin syndrome, a potentially life-threatening condition, reported with concomitant use of serotonergic drugs; this might come about within the encouraged dosage range; the onset of symptoms generally take place within many hrs to a couple of days of concomitant use, but may possibly take place later on than that; discontinue therapy right away if serotonin syndrome is suspected
If coadministration of CYP3A4 inhibitors with fentanyl is essential, keep track of patients for respiratory depression and sedation at Regular intervals and consider fentanyl dose changes right until stable drug effects are realized.
lenacapavir will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
This is much more likely new drug powerful than fentanyl to come about from initiation of elranatamab move-up dosing as many as 14 days after the first treatment dose and during and after CRS.
Due to effects of androgen deficiency, chronic use of opioids may possibly cause diminished fertility in ladies and males of reproductive potential; It isn't known no matter whether effects on fertility are reversible
Critical - Use Alternate (one)fosphenytoin will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of fentanyl with CYP3A4 inducers may lead to the reduce in fentanyl plasma concentrations, not enough efficacy or, perhaps, improvement of the withdrawal syndrome in a very affected person who may have produced Actual physical dependence to fentanyl.
acetazolamide will increase the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unknown.
eluxadoline raises levels of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Caution when CYP3A substrates which have a slender therapeutic index are coadministered with eluxadoline.
sotorasib will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If use is unavoidable, make reference to the prescribing information of your CYP3A4 substrate for dosage modifications
Narcotic agonist-analgesic of opiate receptors; inhibits ascending pain pathways, thus altering reaction to pain; improves pain threshold; creates analgesia, respiratory depression, and sedation
If this happens, take the tablet from your mouth straight away. Rinse your mouth with water and spit any remaining pieces in the tablet into a sink or bathroom.